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Instructions

Write a research paper about the single-trait genetic disorder you selected in Unit III Annotated Bibliography and include the information listed below.

  • Include a thesis statement that clearly and concisely states the paper’s purpose.
  • Describe the single-trait genetic disorder you selected.
  • State whether it is a dominant or recessive disorder.
  • State whether it is sex-linked or autosomal recessive disorder.
  • State the genotype or possible genotypes of a person with the disorder.
  • Relate the genotype to phenotype of a person with the disorder and define phenotype.
  • Describe the symptoms, diagnosis, prognosis.
  • Discuss treatment options, including medicines/alternative treatments.
  • Describe incidence rate or statistics.
  • Describe what can be done to reduce the incidence rates.
  • Include a Punnett square of the parents that could produce offspring with the disorder.
  • Include the ratios of each genotype and phenotype produced by the cross.

Within your discussion of the above items, include definitions for the terms listed below:

  • single-trait genetic disorder,
  • dominant and recessive,
  • sex-linked trait and autosomal disorder,
  • genotype and phenotype, and
  • heterozygous and homozygous.

Include any other interesting facts.

Your research paper must be at least three full pages in length and include an introduction, a body with a review and discussion of literature, and a conclusion. Please include an APA formatted title page. You are required to cite at least two peer-reviewed references, and two of your own choosing, for a minimum of four references. One source must be from the CSU Online Library. You are encouraged to use the references from the Unit III Annotated Bibliography assignment, but it is not a requirement. For more information on locating sources, view the following tutorial:

How to Find Peer-Reviewed Resources

Adhere to APA Style when constructing this assignment, including in-text citations and references for all sources that are used.

Running Head: Annotated Bibliography Page 2

Annotated Bibliography- Sickle Cell Anemia

Alberto Rivera

Dr. Jan Hinnen

Columbia Southern University

August 2nd, 2020

Ahmed, Sagir G. “The Role of Infection in the Pathogenesis of Vaso-Occlusive Crisis In patients With Sickle Cell Disease. Mediterranean Journal of Hematology & Infectious Diseases 3.1 (2011): 1-9. Academic Search Complete. Web. 31 Oct. 2016.

This article shows all the examples of the potential susceptibilities that patients are seen to have against infections, germs and pathogens. The article shows are the significant signs and symptoms that people with sickle cell manifest. The authors clearly show that the disease is a menace and can affect people from all walks of life and therefore should be treated as a public health concern. The disease is believed to make the patient’s immune system to be lower and thus susceptible to other infections and diseases.

The content in this article is critical and relevant to the questions asked as it gives the background information of SCD and all the immunopathological aspects of the disease and hence gives the mental picture of the disease diagnosis, prognosis, and treatment and monitoring on the progress. The article also highlights the demographic patterns of the disease and the people most susceptible giving the age bracket and risk factors. The source also gives insights from other writers on this topic harmonizing all this content into one that is relevant. The source is credible because the author is a professor with several years of experience and credentials that back up the sentiments written.

Campbell, Wilfred Rawventure. “Glutamic Acid: The Amino Acid That Functions Mainly Include Building Muscle and Supporting Brain Function.” Bliss Returned. WordPress, 19 Mar. 2012. Web. 19 May 2015.

The article explains the functions of glutamic acid in the diseases process of Sickle Cell Anemia. This important amino acid is seen to have tremendous effects on the diagnosis and treatment of the disease. This article is relevant as it shows what exactly the body biochemistry does in the event that one has the disease. The pharmacokinetic and dynamic profiles are differentiated and the differences are used by the drug experts to study the SARs of the drugs and the body in the quest to find the most suitable treatments.

DeCapua, Joe. “Sickle Cell Disease Cases Are Increasing.” VOA. VOANews, 18 July 2013. Web. 20 May 2015.

This article sows the trends in the increase in the number of people with the disease and how this disease is transmitted and inherited in the familial linkages. The article also highlights on the risk factors that potentiate and make the disease more chronic in given geographical areas than others. The article also shows the future trend in statistics in terms of race and gender of the people most susceptible to SCD.

Kayle M (2020 May): Impact of Medicaid expansion on access and healthcare among individuals with sickle cell disease external icon. Pediatr Blood Cancer.

The article talks about the impact of SCD to the acute health utilization and the levels of Medicaid in the city of California leading to the levels of Medicaid enrollment in the state. The article depicts on the levels of hydroxyurea utilization and the lack of increased enrollment in hospitals despite the increased levels of diagnosis of SCD. This article was a study that was done on a cohort of 3635 individuals showing their results. This article is reliable as the methodology of study used was extensive and reliable. This study is influential to my study as it shows the future trends in the medical field in the area of SCD.